SYN-1012: A New .BETA.-Lactamase Inhibitor of Penem Skeleton.
نویسندگان
چکیده
منابع مشابه
In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic.
In in vitro susceptibility tests, the new penem CP-70,429 showed potent antibacterial activity against gram-positive and gram-negative bacteria except Pseudomonas aeruginosa and Xanthomonas maltophilia. CP-70,429 was stable to various types of beta-lactamases except for the enzyme from X. maltophilia and was 16- to 128-fold more active than the other compounds against beta-lactamase-producing s...
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The in vivo efficacy of piperacillin in combination with the penem inhibitor BLI-489 was determined using acute lethal systemic infections in mice. On the basis of preliminary results with various ratios, a dosing ratio of 8:1 was found to be optimal for retention of enhanced efficacy. Piperacillin-BLI-489 dosed at an 8:1 ratio was efficacious against murine infections caused by class A (includ...
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OBJECTIVE To determine the susceptibility pattern of beta-lactam beta-lactamase inhibitor combinations against extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae in urinary isolates. STUDY DESIGN Observational study. PLACE AND DURATION OF STUDY Ziauddin University Hospital, Karachi, from February to October 2008. METHODOLOGY A total of 190 consecutive non-duplicate isola...
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Beta-lactamases are the most widespread resistance mechanism to beta-lactam antibiotics, such as the penicillins and cephalosporins. Transition-state analogues that bind to the enzymes with nanomolar affinities have been introduced in an effort to reverse the resistance conferred by these enzymes. To understand the origins of this affinity, and to guide design of future inhibitors, double-mutan...
متن کاملStudies on penem antibiotics. II. In vitro activity of SUN5555, a new oral penem.
The new oral penem antibiotic SUN5555 shows broad antibacterial activity against both aerobic and anaerobic Gram-positive and Gram-negative bacteria. SUN5555 is highly stable against various beta-lactamases. It binds preferentially to the penicillin-binding proteins 2 and 1A of Escherichia coli.
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1997
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.50.350